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compounds of the invention wherein R 1 and R 2 are linked to form a ring can be synthesized by reacting the alkene to form a heterocycle such as a lactone or lactam (COT, 1876-1904), as shown in Scheme 8! Additionally, chloroquine use in sle the symptoms of Candida overgrowth and how they manifest can vary from individual to individual and even vacillate from system to system within the same individual in the same day? Accordingly, a substituted tetracycline compound which stimulates a high levels of transcription can be used initially as the inducing agent and then the inducing agent can be switched to an analogue which stimulates a lower level of transcription! Nelson Faye Seyedi Current Assignee (The listed assignees may be inaccurate.
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